Structure Activity Relationships Investigation in a Class of New Platinum Complexes with 3.5-disubstituted Hydan- Toins and Spiro-5’-hydantoins
نویسندگان
چکیده
Twenty two new Pt(II) and Pt(V) complexes with 3.5-disubstituted hydantoins and spiro-5’hydantoins were synthesized and studied. Pt(II) complexes have been prepared as structural analogues of cisplatin with different carrier ligands. Pt(IV) complexes were with general formula cis-[PtL2Cl4]. Platinum complexes were studied in vitro for cytotoxic activity on panel of human tumor cell lines. The cytotoxicity of new Pt(II) complexes were compared with those of Pt(IV) complexes and the reference cytotoxic drugcisplatin. The tested platinum agents displayed concentration dependent cytotoxic activity at micromolar concentrations. Among the series a Pt(II) complex with 3-benzyl-5-methyl-5-(4-pyridyl)hydantoin as carrier ligand proved to be the most active analogue, whose relative potency in SKW-3 cell line was similar to that of the reference antineoplastic drug cisplatin.
منابع مشابه
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